The Hippo/Yap Pathway Reprograms Glucose Metabolism to Fuel Tissue Growth.
Grant number: 1146558 | Funding period: 2018 - 2020
Completed
Abstract
Liver disease is a common cause of sickness and death in Australia. While factors critical to liver function are known, the cellular networks responsible for causing liver cancer are largely undefined. Our studies will use zebrafish as a model to study how the circuit known as the Hippo pathway reprograms metabolism to promote liver cancer. These studies will enhance our understanding how metabolism regulates liver growth and identify therapeutic targets to combat liver cancer.